PKR Manuscript Data

<p>In this study, a non-bacterial endotoxin mouse model of laparotomy is adopted to address the systemic inflammation triggered by surgery. We aim to investigate whether PKR can be a pharmacological target for preventing both systemic inflammation-triggered neuroinflammation and systemic inflammation-induced cognitive dysfunctions. The aims of the current study are: 1) investigating whether laparotomy induces systemic inflammation, neuroinflammation and cellular changes such as tau phosphorylation leading to cognitive dysfunction; 2) investigating how knockout of PKR in mice modulates systemic inflammation, neuroinflammation and cognitive functions in the laparotomy model; 3) investigating the effects of inhibition of PKR in cholinergic neurons in ChAT-IRES-Cre-eGFP mice on modulating glucose metabolism and cognitive functions in the laparotomy model. Different mouse strains including wild-type C57BL/6J, C57BL/6-Tg(CD68-EGFP)1Drg/J mice, PKR knockout mice, and also ChAT-IRES-Cre-eGFP mice, were used in this project. </p> <p>Data files are in pzfx format. For the imaging data, it is in CZI formats and TIFF formats. Western blot images in SCN format. </p>