Supporting Data for "Histone H3 Lysine 9 Di-methylation Mediates Transcription Regulation on Damaged Chromatin"

<p>Supporting Data for the Thesis Entitled "Histone H3 Lysine 9 Di-methylation Mediates Transcription Regulation on Damaged Chromatin"</p><p>Cells respond to DNA double-strand breaks (DSBs) by inducing transcriptional silencing <i>in cis </i>on the damaged chromatin, which is critical for efficient repair processes. Here we identify H3K9me2 as a novel mediator of transcription silencing on damaged chromatin and present PHF8 as a histone demethylase that promotes timely transcription resumption following DSB repair. </p><p>This supporting data contains raw data in addition to processed data illustrated in the thesis. The raw data consists of quantification files, immunofluorescence images, western blot images, and RT-qPCR data and timelapse photos.</p>