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Supporting Dataset for thesis - "New World vs Old World: Refining the screening, diagnosis, and prediction of oral cancer"

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posted on 2022-12-13, 10:13 authored by John Ademola AdeoyeJohn Ademola Adeoye, Yuxiong SuYuxiong Su

This data contains supporting resources for the thesis titled "New World vs Old World: Refining the screening, diagnosis, and prediction of oral cancer". The thesis was based on eight studies which were generated from the five datasets included in the files. The first dataset (RRBS Dataset) was generated following reduced representation bisulfite sequencing of salivary DNA samples obtained from patients with oral cancer and oral potentially malignant dataset. The differentially methylated CpG sites (CPG Dataset) and differentially methylated regions (DMR Datasets) are provided in different spreadsheets. The second dataset (Bayesian mapping Dataset) comprises counts of oral cancer incidence and mortality in Hong Kong from January 2013 to December 2019. The count was obtained from the CDARS data ecosystem in Hong Kong. The third dataset (Oral cancer prognosis dataset) was obtained with ethical approval from the Hospital Authority Clinical Management System (HA-CMS). It contains information about oral cavity cancer patients in Hong Kong treated at the Queen Mary Hospital from 2000 to 2019. The fourth dataset (Oral cancer screening dataset) was obtained from a community-based oral cancer screening program in Hong Kong conducted between November 2020 to June 2022. Information about demographics, lifestyle, family history, comorbidity, and expired carbon monoxide was collected at these events and presented in the dataset. The fifth dataset (Oral potentially malignant disorders dataset) was also obtained from the HA-CMS for patients with oral leukoplakia and oral lichenoid mucositis to predict malignant transformation. For all datasets, further information explaining individual variables are within the spreadsheets.

Funding

General Research Fund (17114722)

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