Supporting data for ''A Study of the Functional Roles of Nuclear p85β in Ovarian cancer''

Ovarian cancer, the most lethal gynecological malignancy, is characterized by frequent alterations in gene copy number, including amplification of PIK3R2. PIK3R2 encodes the regulatory subunit p85β of class IA phosphoinositide 3-kinase. Although PIK3R2 amplification is linked to a poor prognosis in ovarian cancer, the oncogenic mechanisms driven by p85β, particularly its nuclear functions, are still not well understood. This study thoroughly characterized the transcriptional regulatory landscape governed by nuclear p85β and clarified its role in promoting ovarian cancer progression. This file contains PLA experiment results, western blot images, PCR data, and dual-luciferase reporter data that support this project.