Supporting data for "Current Treatment for Lupus Nephritis Direct Cellular Effects that Impact on Kidney Inflammation and Fibrosis"

This data contain the result from in vivo study including the change in body weight, ACR, BUN, serum creatinine, serum anti-dsDNA antibody levels, and havcr1 and lcn2 mRNA expression in renal cortex.

Immunosuppressive therapy is a part of the standard-of-care of the lupus nephritis, and some of the immunosuppressants were recently revealed their renal protective effects in renal resident cells apart from their immunosuppressive effects. The purpose of this study is to investigate the effects and molecular mechanism of these renal protective effect in renal resident cells. Our in vivo study investigated the effect of immunosuppressive monotherapy on the pro-inflammatory and profibrotic mediators in New Zealand Black and White F1 (NZB/W F1) mice, a well-established lupus-prone murine model. The uploaded results contain the assessment of serological and clinical parameters reflecting the renal function of the experiment mice, including the change in body weight, change in ACR, BUN level, serum creatinine level, serum anti-dsDNA antibody level, and havcr1 and lcn2 mRNA expression in renal cortex.