Supporting data for “Deregulation of RNA acetylation and NAT10 in liver cancer: from molecular mechanism to therapeutics”

Epitranscriptomics is a burgeoning research area that concerning various modifications on RNA. N6-Methyladenosine (m6A) was the most famous and the best characterized modification on eukaryotic mRNA with the known function to affect mRNA splicing, translation, and degradation. While N1-Methylpseudouridine (m1Ψ) was another crucial one that solved the bottlenecks for in vivo mRNA delivery so that made mRNA vaccine possible in the past COVID-19 pandemic.

However, the functions of other mRNA modifications, especially for their roles in human physiology and pathology remain largely unknown. Herein, we revealed the crucial oncogenic functions of N4-acetylcytidine (ac4C) and RNA cytidine acetyltransferase NAT10 in facilitating human liver carcinogenesis.Our work also demonstrated that, RNA cytidine acetyltransferase NAT10 could be a novel and promising therapeutic target for advanced liver cancer treatment.