The study was a two-year double-blind randomised clinical trial. A total of 579 caregiver-child dyads were randomised to test group (children used xylitol toothpaste) and control group (children used fluoride toothpaste) with toothbrushing twice daily for two years. The effectiveness of xylitol toothpaste or fluoride toothpaste in preventing early childhood caries was evaluated and compared.
Funding
The study was funded by the Research Grants Council, Hong Kong (General Research Fund: 17106117).