Supporting data for "Engineering of Inhalable Nanoagglomerate Dry Powders for Treatment of Respiratory Diseases: Rational Development, Characterization, and Evaluation"
<p dir="ltr">This dataset includes supporting data for "Engineering of Inhalable Nanoagglomerate Dry Powders for Treatment of Respiratory Diseases: Rational Development, Characterization, and Evaluation". The studies focused on the development, Design of Experiments-guided optimization, physicochemical characterization, and biological evaluation of inhalable remdesivir and paclitaxel nanoagglomerate dry powder formulations. </p><p dir="ltr">The dataset contains data for the physicochemical characterization of particle size, zeta potential, colloidal stability, drug loading, encapsulation efficiency, and morphology of nanosuspensions; physicochemical characterization of thermal profile, crystallinity, morphology, drug content, flowability, and stability of nanoagglomerate powders; modelling results of Design of Experiments-guided optimization of nanosuspension and nanoagglomerate powders; in vitro aerosol performance, drug release, cellular viability, and cellular uptake data of nanoagglomerate powders; and in vivo biodistribution and efficacy data for the optimized paclitaxel nanoagglomerate powder formulation.</p>
Funding
Health and Medical Research Fund, Health Bureau, HKSAR Government (08191956)
Health@InnoHK, Innovation and Technology Commission, HKSAR Government
Leung Kau Kui and Run Run Shaw Research and Teaching Endowment Funds, The University of Hong Kong