Supporting data for “Host and Viral Predictive Factors of Spontaneous Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B Patients”

This is a retrospective longitudinal case-control study that use data and plasma archive collected in the Queen Mary Hospital, Hong Kong from 2005-2021.

120 chronic hepatitis B patients who lost HBsAg (refer to S-losers thereafter) were age-matched and sex-matched with those who remained positive for HBsAg in a 1:1 ratio (240 patients in total). Plasma level of anti-HBc level, cytokines (IP-10, IL-21, IL2) level, and HBV spliced variants (Sp13, Sp1) level were quantified at 0-1 years before (0 to -1 Year), 1-3 years before (-1 to -3 Year), 3-5 years before (-3 to -5 Year), 5-8 years before (-5 to -8 Year), 8-10 years before (-8 to -10 Year) HBsAg seroclearance (or reference point for the control group).