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Supporting data for 'Immunomodulation by Systemic Administration of Exosome Derived from Induced Pluripotent Stem Cell Mesenchymal Stem Cells to AlleviateLiver Inflammation and FibrosisinWilson’s disease'

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posted on 2025-03-28, 07:07 authored by Yang HuYang Hu

Exosomes derived from mesenchymal stem cells (MSCs) are proposed to have anti-inflammatory and immunomodulation effects. We sought to determine the therapeutic effects of human induced pluripotent stem cell (hiPSC)-MSC derived exosomes to alleviate liver inflammation and fibrosis in Wilson’s disease (WD).

Our findings demonstrated that hiPSC-MSC-Ex could ameliorate hepatic fibrosis in the WD mouse model via immunomodulation and macrophage polarization. These results support the development of hiPSC-MSC-Ex as a cell-free therapy for WD as well as other chronic liver diseases.

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