Supporting data for 'Immunomodulation by Systemic Administration of Exosome Derived from Induced Pluripotent Stem Cell Mesenchymal Stem Cells to AlleviateLiver Inflammation and FibrosisinWilson’s disease'

Exosomes derived from mesenchymal stem cells (MSCs) are proposed to have anti-inflammatory and immunomodulation effects. We sought to determine the therapeutic effects of human induced pluripotent stem cell (hiPSC)-MSC derived exosomes to alleviate liver inflammation and fibrosis in Wilson’s disease (WD).

Our findings demonstrated that hiPSC-MSC-Ex could ameliorate hepatic fibrosis in the WD mouse model via immunomodulation and macrophage polarization. These results support the development of hiPSC-MSC-Ex as a cell-free therapy for WD as well as other chronic liver diseases.