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Supporting data for "Investigating the impacts of periodontitis on neuroinflammation, neuropathology, and neurodegeneration of Alzheimer's disease"
Systemic activation of the immune system can exert detrimental effects on the central nervous system. Periodontitis, a chronic disease of the oral cavity, is a common source of systemic inflammation. Neuroinflammation might be a result of this to accelerate progressive deterioration of neuronal functions during aging or exacerbate pre-existing neurodegenerative diseases such as Alzheimer’s disease (AD). This study aimed to investigate the impacts of periodontitis on AD.
The dataset is organized into five different sub-categories: Aging, Bacterial-induced Periodontitis, Ligature-induced Periodontitis, Doxycycline Treatment, and Cytokine Injection. For each sub-category, an XLSX file named "Animal Overview" is included, which contains all information regarding the batch number, date of experiment, species, animal ID, date of birth, sacrificing date, treatments, and behavioral tests performed. All files in this dataset include images in SCN/CZI/TIF/BMP formats, behavioral videos in AVI format, individual data points in CSV format, and results in XLSX format. Analysis of immunofluorescence images in SCN format and western blot images in TIF and CZI formats was done using Image J software. Analysis of behavioral videos in AVI format was done using Smart 3.0 video tracking software.