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Supporting data for "Long non-coding RNAs modulate the osteogenic differentiation of healthy and inflamed periodontal ligament cells"

posted on 23.11.2021, 10:08 by Yifan LinYifan Lin

Periodontitis is a bacteria‐induced and host‐mediated inflammatory disease that results in the progressive destruction of tooth-supporting tissues and bone. Yet, it is closely associated with various inflammatory comorbidities like cardiovascular disease, diabetes mellitus, and Alzheimer’s disease. Periodontal ligament (PDL), a thin layer of connective tissue between the cementum and alveolar bone, contributes significantly to the development, function, and regeneration of periodontium. The PDL progenitor cells (PDL cells) have multipotent differentiation potential and are considered as an appropriate source of periodontal regeneration for the treatment of periodontitis.

The PDL cells have reduced osteogenic potentials in periodontitis patients, with reference to the periodontally healthy individuals. Currently, the primary goal of periodontal therapy is to stop disease progression and achieve a stable periodontal condition. However, it is unknown whether the regenerative potentials of the treated stable periodontium can be fully recovered following periodontal therapy. Therefore, it becomes increasingly important for enhancing the osteogenic potential and ultimately promoting bone formation in periodontally compromised patients.

Long non-coding RNAs (LncRNAs) as the critical regulators of diverse biological processes and diseases are involved in the osteogenic differentiation of PDL cells. The current work aimed to elucidate the characteristics and osteogenic potentials of healthy, inflammatory, and treated stable PDL cells, and explore the regulation of lncRNAs in the osteogenic differentiation of these cells.