Supporting data for "Mitochondrial protein Coiled-Coil-Helix-Coiled-coil-Helix Domain 10 (CHCHD10) as a novel contributor to heart failure through controlling microtubule organization"

Coiled-Coil-Helix-Coiled-coil-Helix Domain 10 (CHCHD10) is a mitochondrial protein located in the mitochondrial intermembrane space and has been identified as a regulator of mitochondrial oxidative phosphorylation (OXPHOS). We aimed to investigate the role of CHCHD10 in the heart and its underlying mechanisms in the pathogenesis of heart failure. Our findings discovered severe heart failure in cardiac CHCHD10-deficient mice, accompanied by pathological alterations of cardiac metabolism, mitochondrial dysfunction, and disruption of microtubule networks. In summary, these data suggested that cardiac CHCHD10 may play an important role in the maintenance of cardiac function.