File(s) under embargo
1
year(s)11
month(s)until file(s) become available
Supporting data for "Modulation of alpha-4 beta-2 nicotinic acetylcholine receptor attenuates systemic inflammation and neuroinflammation triggered by laparotomy"
The scope of the data in this research project focuses on investigating the effects of an alpha-4 beta-2 nicotinic acetylcholine receptor agonist targeting postoperative neuroinflammation and cognitive decline in a murine model. The study includes a sample size of 150 mice, encompassing surgery group, surgery + agonist group and anaesthesia groups, to assess the therapeutic potential of the these agonists in mitigating neuroinflammatory responses and cognitive impairments following surgery.
The data files comprise behavioral evaluations related to cognitive function, neuroinflammatory markers like pro-inflammtory cytokine or anti-inflmmatory cytokine, glial cell activation including astrocyte staining and microglia staining, as well as protein markers related to synaptic plasticity and memory function. This study offers a detailed insight into the experimental outcomes and molecular changes associated with the agonist treatment, aiming to elucidate the mechanisms underlying its neuroprotective and cognitive-enhancing properties.