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Supporting data for "New chemical probes for chemoproteomic profiling and redox biology investigation"

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posted on 2024-05-21, 01:13 authored by Hin Yuk LaiHin Yuk Lai

Emerging evidence presented the significance of cellular redox signalling in regulating protein expression and activity, hence modulating cancer proliferation and metastasis.
The signalling was mediated by redox-active species that induce reversible redox modifications on amino acid residues, such as cysteine Oxidative post-translational modification (OxiPTM). This led to dynamic regulation of cellular events, including survival, proliferation, and metastasis.
Yet, the underlying molecular mechanism of many redox signalling pathways remained undetermined. The transient and short-lived characteristics of redox species and the corresponding redox modification challenged the capture of the signalling process and recognition of the associated protein targets.
The thesis presented the synthesis and application of two chemical probes incorporated with the chemoproteomic approach to study cellular redox signalling from two perspectives: (1) the cysteine OxiPTM upon ROS stimulation and (2) the superoxide-induced proximity modification of proteins associated with superoxide biology.

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