Supporting data for "New chemical probes for chemoproteomic profiling and redox biology investigation"

<p dir="ltr">Emerging evidence presented the significance of cellular redox signalling in regulating protein expression and activity, hence modulating cancer proliferation and metastasis.<br>The signalling was mediated by redox-active species that induce reversible redox modifications on amino acid residues, such as cysteine Oxidative post-translational modification (OxiPTM). This led to dynamic regulation of cellular events, including survival, proliferation, and metastasis.<br>Yet, the underlying molecular mechanism of many redox signalling pathways remained undetermined. The transient and short-lived characteristics of redox species and the corresponding redox modification challenged the capture of the signalling process and recognition of the associated protein targets.<br>The thesis presented the synthesis and application of two chemical probes incorporated with the chemoproteomic approach to study cellular redox signalling from two perspectives: (1) the cysteine OxiPTM upon ROS stimulation and (2) the superoxide-induced proximity modification of proteins associated with superoxide biology.<br></p>