Supporting data for "Preclinical Evaluation of Macrophage-Targeted Therapies in Esophageal Squamous Cell Carcinoma Using PatientDerived Organoid Xenograft Models"

<p dir="ltr">All the data from my PhD were uploaded here including a readme file, which includes a full description on the </p><p dir="ltr">Description on the project:</p><p dir="ltr">Esophageal squamous cell carcinoma (ESCC) carries a poor prognosis and is frequently complicated by cancer cachexia. Suitable pre-clinical models that capture both tumor biology and systemic wasting are limited.</p><p dir="ltr">Overall, the study delivers a comprehensive pre-clinical framework, spanning PDOX model development, cachexia modelling, and macrophage-targeted therapy, that (i) faithfully recapitulates ESCC and its cachexia, (ii) demonstrates that CSF1R blockade or PPAR-γ activation mitigates wasting, (iii) shows that DAC augments myeloid depletion and, in combination with PLX3397, achieves synergistic tumor control, and (iv) defines functional TAM subsets as therapeutic targets. These findings support dual TAM-targeted strategies to simultaneously alleviate cachexia and improve tumor control in ESCC.</p>