Supporting data for “Protective Effects of IL-11 on Experimental Intracerebral Hemorrhage”
This research aims to investigate the effects of IL-11 on intracerebral hemorrhage (ICH). An autologous blood ICH rat model was established. Using this model, the impact of ICH on neurological functions, brain edema, as well as the level and cellular expression of IL-11 was measured. Then IL-11 was injected into ICH rats. The neurological function, hematoma volume, brain edema, level of inflammation, apoptosis and neurogenesis were measured. Next, an in vitro ICH model was established by exposing differentiated SH-SY5Y cells to hemin. Upon IL-11 administration, cell viability, apoptosis, and IL-11 signaling pathway STAT3/Bcl-2 expression were evaluated.