This dataset contains the disease activity of SARS-CoV-2 in Hong Kong from the our established surveillance system, from March 2022 to 2023. This data is used in the thesis to measure the daily point prevalence of SARS-CoV-2 activity in Hong Kong and to explore the impact of control measures during the fifth waves. Data for other Chapters are authorized by the primary supervisor, the data will not be uploaded and this has been approved by the primary supervisor.