HKU Data Repository
Browse

Supporting data for "Studies on ovarian follicle development translating basic research to female infertility treatment"

dataset
posted on 2025-01-27, 06:39 authored by Yihui ZhangYihui Zhang

This study evaluated three anti-inflammatory drugs—curcumin, loteprednol etabonate (LE), and ibuprofen—to explore their effects on primordial follicle activation. Curcumin and LE promoted the development of small ovarian follicles in neonatal mouse ovaries in vitro, which greatly potentiated these follicles for subsequent in vivo development into antral follicles after transplantation into the recipient mice. Furthermore, curcumin has been shown to promote the survival and development of small follicles in human ovaries, suggesting its potential use in IVA treatments. Conversely, ibuprofen did not affect the development of ovarian follicles in mice, both in vivo and in vitro.

Further mechanistic studies aimed at elucidating how curcumin and LE promote small follicle development revealed that both drugs can activate the PI3K signaling pathway. They stimulated granulosa cell proliferation and inhibited apoptosis in ovarian cells. RNA sequencing of LE-treated neonatal mice ovaries provided additional insights into how LE might facilitate follicular development.

History

Usage metrics

    Research Postgraduates

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC