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Supporting data for The Functional Roles of SCD1/FADS2 Lipid Desaturases in Modulating Lipid Metabolic Activities and Redox-driven Ferroptosis in Ascites-derived Ovarian Cancer Cells

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posted on 10.08.2021, 09:02 by Yang XuanYang Xuan

1. The desaturation abilities of SCD1/FADS2 are aberrantly augmented in ascites-derived ovarian cancer cells.

2. SCD1/FADS2 causes the elevation of poly- and mono-unsaturated fatty acids (UFAs) and enhanced oncogenic properties of ovarian cancer cells.

3. SCD1/FADS2 modulates GSH/GSSG ratio and GPX4, preventing induction of ferroptosis.

4.Targeting suppression of SCD1/FADS2 synergistically enhances cisplatin-mediated cytotoxicity in ascites-derived ovarian cancer cells.

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