Supporting data for "The eradication of deep-seated infections induced by antibiotic-resistant bacteria using purposely designed stimulus-responsive biomaterials"

The rapid emergence and dissemination of drug-resistant bacteria undoubtedly poses a serious challenge to global public health. Developing new antibiotics has proved to be a feasible approach to coping with such drug-resistant bacteria; however, the development of new antibiotics consistently lags behind the emergence of new drug-resistant bacteria. Moreover, antibiotics treatments for deep-seated infections often fail because antibiotics are unable to reach the infection sites precisely. Hence, in this study, advanced exogenous technology (i.e., light, ultrasound, and microwave) stimuli-responsive biomaterials were fabricated to overcome drug-resistant bacteria in deep tissues. Under exogenous stimulation, the stimuli-responsive biomaterials rapidly produced bactericidal reactive oxygen species (ROS) and/or heat through electron transfer and a series of REDOX reactions. 

Meanwhile, the data include the characterization of stimulus-responsive biomaterials ( i.e., SEM, TEM, XRD, and so on), photothermal tests, photodynamic tests, sonodynamic tests, microwave thermal tests, in vitro antibacterial tests, in vitro cell regulation, in vivo antibacterial tests, in vivo bone regeneration, in vivo immunofluorescence technique, and so on. Details could be found in the dataset.