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Supporting data for "The eradication of deep-seated infections induced by antibiotic-resistant bacteria using purposely designed stimulus-responsive biomaterials"

posted on 2022-07-18, 06:52 authored by Congyang MaoCongyang Mao, Kelvin Wai Kwok YeungKelvin Wai Kwok Yeung

The rapid emergence and dissemination of drug-resistant bacteria undoubtedly poses a serious challenge to global public health. Developing new antibiotics has proved to be a feasible approach to coping with such drug-resistant bacteria; however, the development of new antibiotics consistently lags behind the emergence of new drug-resistant bacteria. Moreover, antibiotics treatments for deep-seated infections often fail because antibiotics are unable to reach the infection sites precisely. Hence, in this study, advanced exogenous technology (i.e., light, ultrasound, and microwave) stimuli-responsive biomaterials were fabricated to overcome drug-resistant bacteria in deep tissues. Under exogenous stimulation, the stimuli-responsive biomaterials rapidly produced bactericidal reactive oxygen species (ROS) and/or heat through electron transfer and a series of REDOX reactions. 

Meanwhile, the data include the characterization of stimulus-responsive biomaterials ( i.e., SEM, TEM, XRD, and so on), photothermal tests, photodynamic tests, sonodynamic tests, microwave thermal tests, in vitro antibacterial tests, in vitro cell regulation, in vivo antibacterial tests, in vivo bone regeneration, in vivo immunofluorescence technique, and so on. Details could be found in the dataset.


National Key R&D Program of China (2018YFA0703100)

General Research Fund of Hong Kong Research Grant Council (nos. 17207719 and 17214516)

Hong Kong Health and Medical Research Fund (nos.19180712, 20190422 and 21200592)

Innovation and Technology Fund Partnership Research Program (PRP/030/30FX)

the National Science Fund for Distinguished Youth Scholar (no. 51925104)

Shenzhen Science and Technology Funding (nos. JSGG20180507183242702 and JCYJ20210324120009026)

Sanming Project of Medicine in Shenzhen “Team of Excellence in Spinal Deformities and Spinal Degeneration” (SZSM201612055)