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Supporting data for " The impact of CXCL10 derived from ovarian cancer cells on CD8+ T cell antitumor immunity"
The TME in ovarian cancer is highly immunosuppressive, encompassing multiple inhibitory ligands, suppressive mediators, and various cell subsets, which results in CD8+ T cell dysfunction and exhaustion and subsequently limits the effectiveness of immunotherapeutic strategies. Numerous human studies have underscored the potential significance of chemokines in influencing the status of T-cell infiltration into tumors and patient survival. The effect of tumor-derived CXCL10 on T cells re- mains unclear. Therefore, our investigation is focused on understanding the func- tional impact and regulatory mechanisms of ovarian cancer-derived CXCL10 on the antitumor immunity of CD8+ T cells.
Our objectives of this research is (1) to investigate the relationship between ovarian tumor cell-derived CXCL10 and CD8+ T cell exhaustion, (2) to investigate the impact of tumor-derived CXCL10 on CD8+ T cell antitumor immunity, and (3) to delineate the molecular mechanisms by which tumor-derived CXCL10 regulates CD8+ T cell exhaustion.
This dataset includes four folders. Folder 1: Quantitative analysis data. Include Differential genes of single-cell analysis in CD8 T cells from patients with CXCL10 high versus CXCL10 low in tumor cells; Differential genes analysis of RNA-seq data of tumor tissue from orthotopic ovarian mouse model formed by CXCL10-/- and CXCL10-WT cells; Information of ovarian cancer patient tissue arrays; Quantitative analysis of tissue arrays. Quantitative of tumor growth of orthotopic ovarian mouse model and metastatic implantation model.
Folder 2: Multiplex Immunohistochemistry Images of ovarian cancer patient tissue arrays; H&E and Multiplex Immunohistochemistry images of tumor tissue orthotopic ovarian mouse model formed by CXCL10-/- and CXCL10-WT cells.
Folder 3: Images of monitoring tumor growth of orthotopic ovarian mouse model and metastatic implantation model.
Folder 4: RPG poster in PDF File.