Ischemic stroke (IS) is the second leading cause of death worldwide and lacks an effective treatment. Fatty acid-binding protein 4 (FABP4) has been found to be related to IS particularly in clinical studies. Its inhibitor, BMS309403, has been found to be beneficial in a cluster of metabolic diseases. However, whether and how FABP4 inhibitor would protect IS remain obscure. In this study, the role of FABP4 in IS pathogenesis was investigated both in vivo and in vitro. The experimental data include two types: quantified data are presented in pzfx format, and pictures are presented in jpg/tif format.