Supporting data for "Antiviral Activities of Live Attenuated Influenza Virus-vectored Vaccine Against SARS-CoV-2 Infection in Lung Epithelial Cells"

This is the complete dataset for the thesis "Antiviral activities of live attenuated influenza virus-vectored vaccine against SARS-CoV-2 infection in lung epithelial cells".

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Influenza A virus (IAV) are two of the major respiratory disease-inducing viruses that have caused global pandemic. The co-circulation of the two viruses is of concern for posing potential threat to public health. However, the characteristic of IAV triggering a robust and early innate immune response makes IAV-vectored virus particle a potential tool for therapeutic strategy for management of SARS-CoV-2 infection. This research study aimed to assess the efficacy of using live attenuated influenza virus vector-based COVID19 vaccine as antiviral intervention against SARS-CoV-2 infection, by the use of cell-based in vitro models involving human or mouse lung epithelial cells as well as immune cells.

All experiments involving live SARS-CoV-2 viruses were conducted following approved standard operative procedures in biosafety level 3 facility in the Department of Microbiology of The University of Hong Kong.

Detailed methodology can be found in the "Chapter 2. Materials and Methods" of the thesis.

All data are included in the dataset main folder. The file directory and description for the dataset can be found in the README.txt file.