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Supporting data for "smart self-assembled nanoparticles for the treatment of age-related macular degeneration"
The thesis project aims to develop stimuli-responsive nanoparticles by self-assembling prodrugs for minimally invasive administration of age-related macular degeneration, including designing reactive oxygen species (ROS)-responsive prodrug nanoparticles and photoactivatable prodrug nanoparticles. The methods include the synthesis and characterization of stimuli-responsive prodrugs, the characterization of formulations, in vitro data of anti-angiogenic assays, and in vivo therapeutic and biosafety data in choroidal neovascularization mouse models.
