<p dir="ltr">This project aims to explore how EV-derived miRNAs contribute to the pathogenesis of the HPAI H5N1 virus, and evaluate their potential as therapeutic options for HPAI virus infection.</p><p dir="ltr"><br></p><p dir="ltr">The Chapter 4 dataset addresses Research Objective 1, focusing on immune regulation by targeted miRNA mimics. The processed data was analyzed using GraphPad Prism software. The Prism files of each figure were included in the dataset, with the figure number indicated in the file header.</p><p dir="ltr">The Chapter 5 dataset addresses Research Objective 2, examining immune regulation by targeted miRNA inhibitors. The processed data was analyzed using GraphPad Prism software. The Prism files of each figure were included in the dataset, with the figure number indicated in the file header.</p><p dir="ltr">The Chapter 6 dataset covers the Research Objective 3, investigating downstream signaling molecules. Data from the nCounter detection platform were summarized in excel format files, and the file were further analyzed using R.</p><p dir="ltr"><br></p>