Supporting data for "Effects of inflammation on the aged periodontium via NF-κB/FOXO3a/c-JUN signalling"

Ageing is widely recognized as a major risk factor for numerous chronic inflammatory diseases. The pro-inflammatory state observed in ageing individuals may serve as a biomarker of the rate of ageing. Elevated concentrations of pro-inflammatory markers in older individuals have been found to be associated with an increased risk of age-related diseases and various chronic conditions. Coinciding with other chronic diseases, periodontal disease increases in prevalence and severity with ageing. The periodontal ligament (PDL) is a key component of the periodontium, and periodontal ligament cells (PDLCs) play a vital role in the process of periodontal remodeling. However, the specific mechanisms that connect inflammation with ageing in the periodontium remain unclear. The aim of this study was to investigate the effect of inflammation on the senescence phenotype and bone metabolism of the aged periodontium and to explore the molecular mechanisms underlying this effect.