Supporting data for "Hyperandrogenism-associated central obesity and metabolic disorders are related to mesothelial cell loss and adipose remodeling in visceral adipose tissue"

Hyperandrogenism is an important diagnostic criteria in polycystic ovary syndrome, which is usually accompanied with central obesity and metabolic disorders. But the link between these metabolic disorders and high levels of androgens remains unclear. Chronic hyperandrogenism leads to central obesity, systemic metabolic disorder and adipose tissue inflammation, with significant loss of extracellular matrix in visceral adipose tissue. Mechanistically, hyperandrogenism enhances Inmt expression in mesothelial cells which in turn induces apoptosis. Both the absence of mesothelial cells and the reduced DCN expression in mesothelial cells result in reduced DCN in adipose tissue and impaired ECM assembly, leading to ECM loss. This event eventually culminates in central obesity and metabolic disorders.