Supporting data for “Preventing proximal caries in neighboring tooth with glass ionomer cement restoration and silver diamine fluoride pretreatment ”

To enhance the antimicrobial effect of GIC restoration, this study used silver diamine fluoride (SDF) solution as dentin pretreatment prior to GIC restoration. The first laboratory study assessed the fluoride and silver ion release of GIC restorations, including CGIC and RMGIC restorations, with 38% SDF solution dentin pretreatment. The results showed that 38% SDF dentin pretreatment sustainably increased the fluoride and silver release of GIC restorations for up to 2 years. Hence, the following laboratory studies used an in vitro model to investigate the enamel caries preventive effects of 38% SDF pretreatment on neighboring tooth proximal to GIC restorations. The results indicated that SDF pretreatment enhanced the preventive effect of GIC on proximal enamel surface on neighboring tooth through inhibiting cariogenic biofilm, reducing enamel demineralization and promoting enamel remineralization. After that the preventive effects of 38% SDF pretreatment on GIC restorations against root caries on neighboring tooth was investigated. The results showed that SDF pretreatment enhanced the preventive effect of GIC on the proximal dentin surface of neighboring tooth by inhibiting cariogenic biofilm, dentine demineralization and collagen degradation. The fourth laboratory study was performed to develop an antimicrobial silver zeolite glass ionomer cement (SZ-GIC) and determine its biocompatibility, physical, adhesive and antibacterial properties. The results showed that SZ-GIC exhibited enhanced physical, adhesive and antibacterial properties compared to GIC.