Supporting data for "BIS(N-HETEROCYCLIC CARBENE) PLATINUM(II), CIS-DIAMMINE PLATINUM(II) AND N,N’-DISUBSTITUTED CYCLIC THIOUREA SILVER(I) COMPLEXES: SYNTHESIS, ANTI-CANCER PROPERTIES AND MECHANISM OF ACTION STUDIES"

Our society is facing increasing burden of health care associated with cancer disease. At present, there are more than hundreds of anti-cancer drugs. At the same time, the number of compositions made from these clinically approved anti-cancer drugs is up to 1300-1500.[1] Among the clinically used anti-cancer drugs, cytotoxic platinum (II) compounds are the most extensively used in chemotherapy. In this project, the platinum(II) complexes bearing different bis-N-heterocyclic carbene and 1- (3-hydroxybenzo[b]thiophen-2-yl)ethanone (HO^O) ligand were examined and studied for their anti-cancer properties. NHC is a strong σ-donor ligand that can form stable metal- C bonds with transition metal ions.