Supporting data for “Design, Synthesis and Biological Evaluation of Novel CDK Modulators”

The findings documented in this thesis primarily investigated the development of selective anticancer drugs targeting the CDK7 protein. Through strategies such as conformational restriction and scaffold hopping, a series of highly active selective small molecule CDK7 inhibitors have been designed and synthesized, demonstrating good enzymatic and cellular activities. Furthermore, based on the novel selective CDK7 inhibitors, corresponding protein degraders have been further developed. These research findings will contribute to the development of novel anticancer drugs.