This dataset supports a study characterizing leukemia in zebrafish through experimental and transcriptomic analyses, using zebrafish as a model organism to investigate the biological and molecular features of leukemia. The research includes phenotypic observations, histological examinations, and transcriptomic profiling in wild-type and genetically modified zebrafish strains designed to mimic leukemia-like conditions. The dataset comprises experimental records, and processed RNA-seq data, and gene expression summaries, offering insights into leukemia progression. No sensitive or confidential information is included.