This README.txt file was generated on <20210929> by <Jaydeep Roy>



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GENERAL INFORMATION
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1. Title of Dataset: Supporting data for "Melatonin enhances cognition and hippocampal neurogenesis in animal models of Alzheimer's disease and retinal degeneration"


2. Author Information


First Author Contact Information
    Name: Jaydeep Roy
    Faculty: Medicine
    Email: jaydeep@connect.hku.hk



Corresponding Author Contact Information
    Name: Lee Wei Lim
    Faculty: Medicine 
    Email: limlw@hku.hk


Author Contact Information 
    Name: Man Lung Fung
    Faculty: Medicine
    Email: fungml@hku.hk


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DATA & FILE OVERVIEW
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Directory of Files:
   A. Filename: Dataset        
      Short description: Figure 2.1: Trend of melatonin-related research in preclinical and clinical fields of AD from 1997 to 2020.
                         Figure 4.1: Effect of Melatonin treatment on the behavioral outcomes in 5xFAD and WT animals.
                         Figure 4.2: Effect of Melatonin treatment on the amyloid plaque percentage in 5xFAD animals.
                         Figure 4.3: Effect of Melatonin treatment on the number of microglial cells in 5xFAD and WT animals.
                         Figure 4.4: Effect of Melatonin treatment on the number of mature and immature neuronal cells in 5xFAD and WT animals.
                         Figure 4.5: Effect of Melatonin treatment on the number of hippocampal cell proliferation and neurogenesis in 5xFAD and WT animals.
                         Figure 5.1: Effect of Melatonin treatment (2-week) on the retinal and visual cortical functions in rd10 animals.
                         Figure 5.2: Effect of Melatonin treatment (4-week) on the retinal function in rd10 animals.
                         Figure 5.3: Effect of Melatonin treatment (4-week) on the visual cortical function in rd10 animals.
                         Figure 5.4: Effect of Melatonin treatment (4-week) on the behavioral outcomes in rd10 and WT animals.
                         Figure 5.5: Effect of Melatonin treatment (4-week) on the number mature and immature neuronal cells in rd10 and WT animals.
                         Figure 5.6: Effect of Melatonin treatment (4-week) on the number of hippocampal cell proliferation and neurogenesis in rd10 and WT animals.
                         Figure 5.7: Effect of Melatonin treatment (4-week) on the expression of neuroplasticity-related proteins in rd10 and WT animals.
                         Figure 5.8: Effect of Melatonin treatment (2-week) on the number of primary visual cortical cells in rd10 animals. 
                         Figure 5.9: Effect of Melatonin treatment (2-week) on the number of mature and immature neuronal cells in rd10 animals.
                         Figure 5.10: Effect of Melatonin treatment (2-week) on the number of hippocampal cell proliferation and neurogenesis in rd10 animals.
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DATA DESCRIPTION FOR: [Dataset]
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METHODOLOGICAL INFORMATION
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1. Software-specific information:


Name: ANY-maze
Version: 6.35
System Requirements: Windows (32- and 64-bit)
Open Source? (Y/N): N 


Executable URL: N/A
Source Repository URL: N/A
Developer: Global Biotech Inc.
Product URL: N/A
Software source components: N/A

Additional Notes: N/A


Name: Fiji (ImageJ)
Version: 2.3.0
System Requirements: Any (Java-based)
Open Source? (Y/N): Y 


Executable URL: N/A
Source Repository URL: N/A
Developer: Johannes Schindelin, Ignacio Arganda-Carreras, Albert Cardona, Mark Longair, Benjamin Schmid, and others
Product URL: N/A
Software source components: N/A

Additional Notes: N/A


Name: Image Lab
Version: 6.1
System Requirements: Windows, Mac
Open Source? (Y/N): Y 


Executable URL: N/A
Source Repository URL: N/A
Developer: Bio-Rad Laboratories
Product URL: N/A
Software source components: N/A

Additional Notes: N/A




2. Equipment-specific information:


Manufacturer: N/A
Model: N/A

Embedded Software / Firmware Name: N/A
Embedded Software / Firmware Version: N/A
Additional Notes: N/A